Amy Schumer weight loss became a trending topic in 2025 after the comedian revealed she had lost weight with the help of medication—specifically Ozempic. Schumer openly discussed using the drug to manage weight gain caused by endometriosis and hormonal imbalances, adding a layer of honesty that resonated with fans and critics alike.

Amy Schumer, known for her unfiltered humor and body-positive stance, shocked fans in 2025 when she appeared noticeably slimmer. Unlike many celebrities who avoid the topic, Schumer spoke candidly about her experience, stating that Ozempic played a key role in her transformation.
She explained that her weight struggles were tied to endometriosis surgery and other hormonal issues. The comedian emphasized that her goal wasn’t just aesthetics, but about feeling healthy and energized, especially after becoming a mother.
“I want to be honest because everyone lies about this,” she said on Watch What Happens Live with Andy Cohen. “I used Ozempic and it worked.”
Amy Schumer Weight Loss and Ozempic: The Facts
What Is Ozempic?
Ozempic (semaglutide) is an FDA-approved medication for type 2 diabetes that also promotes weight loss by suppressing appetite and regulating blood sugar. It has become increasingly popular among celebrities and influencers.
Amy’s Honest Take
Schumer didn’t shy away from naming the drug, calling out Hollywood for not being transparent about its use. Her openness sparked discussions around body image, medical intervention, and celebrity responsibility.
Amy Schumer Before and After Weight Loss
Photos circulating across social media and in entertainment publications highlight the dramatic changes in Schumer’s physique. Her weight loss before and after comparisons show a noticeable drop in pounds, particularly around her waist and face.
While exact figures weren’t shared, experts estimate she may have lost between 20–30 pounds over the course of her journey.
Amy Schumer Weight Loss 2025: What Changed?
In 2025, Amy continued to focus on wellness, combining Ozempic with lifestyle changes. She’s reported to have:
- Cut back on processed foods
- Added moderate daily movement like walking and yoga
- Managed hormonal fluctuations post-surgery
Though Ozempic played a leading role, Schumer emphasized that balance and self-care were essential to maintaining results.
Amy Schumer Weight Loss Medication: Was It Safe?
Amy’s transparency raised questions: Is Ozempic safe for non-diabetic users? Doctors say it can be effective under medical supervision, but it’s not a substitute for a healthy lifestyle.
Schumer noted that she experienced side effects like fatigue and appetite changes, but ultimately found it beneficial in managing both her weight and her overall health post-endometriosis treatment.
Related Celebrity Journeys
For similar stories, explore:
- Paula Deen’s Weight Loss: How the Southern chef lost weight without Ozempic.
- Shea McGee’s Weight Loss: Her transformation and the rumors around medication use.
Final Thoughts: Amy Schumer Now
Amy Schumer’s weight loss journey is more than a celebrity makeover story—it’s about transparency, health challenges, and honesty in a world of curated perfection. At a time when many hide behind vague “lifestyle changes,” Schumer’s willingness to name her medication and share her struggles sets her apart.
As noted on her Wikipedia page, Amy has always blended comedy with raw truth—and her approach to weight loss is no different.
FAQs About Amy Schumer’s Weight Loss
🔹 Did Amy Schumer take Ozempic?
Yes. Amy confirmed she used Ozempic to help with weight loss related to hormonal imbalances after endometriosis surgery.
🔹 What does Amy Schumer look like before and after weight loss?
Amy appears noticeably slimmer, especially in her face and waist, with estimates of a 20–30 pound weight loss.
🔹 What weight loss medication did Amy Schumer use?
Amy Schumer used Ozempic (semaglutide), a drug often prescribed to manage diabetes and support weight loss.
🔹 What year did Amy Schumer lose weight?
Her weight loss became widely noticed in 2025, after she spoke openly about using medication and prioritizing her health.
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